Prof Tara Spires-Jones
Fellow - Academy of Medical Sciences
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Biography
Tara is a Fellow at the Academy of Medical Sciences, professor of neurodegeneration at the University of Edinburgh and one of the UK’s outstanding dementia researchers.
Her work focuses on mechanisms of neurodegeneration in Alzheimer’s disease.
Her first important discovery is that soluble forms of amyloid beta and tau both accumulate within synapses where they contribute to degeneration and cognitive decline.
The second major finding relates to the spread of tau pathology through the brain in AD which correlates strongly with cognitive symptoms.
Tara has also made important discoveries linking two genetic risk factors for Alzheimer’s disease to synaptic degeneration and has contributed to understanding of synapse degeneration in dementia with Lewy bodies, motorneurone disease, and schizophrenia.
Declaration of any potential conflicts of interest
Tara is an academic at the University of Edinburgh. In addition, she has received payments for consulting, grant reviews, scientific talks, or collaborative research over the past 10 years from AbbVie, Sanofi, Merck, Scottish Brain Sciences, Jay Therapeutics, Cognition Therapeutics, Ono, Novo Nordisk, Eisai, and Boehringer Ingelheim, and directs a company Spires-Jones Neuroscience, Ltd.